Allergy Resources

Unconfirmed penicillin allergies and the use of alternative (second-line) antimicrobial agents have been associated with treatment failure, higher incidences of C. difficile, and longer hospital stays.

Cefazolin does not share a side-chain with any other beta-lactam and can be used in nearly all cases of beta-lactam allergies (unless the patient has a cefazolin allergy).

The majority of patients (>80%) with a severe beta-lactam allergy no longer have an allergy and are able to tolerate beta-lactam antibiotics within 10 years.

Graded Challenge Guidance Document (PDF)
Northwestern Memorial Hospital

Beta-lactam Allergy Questionnaire (PDF)

Northwestern Medicine
Antimicrobial and Diagnostic Stewardship Program

Allergy Resources

Beta-lactam Allergy risk assessment

CROSS-REACTIVITY SIDE-CHAIN CHART

Northwestern Medicine Antimicrobial and Diagnostic Stewardship Program